中文名稱

Bacillus anthracis, Cell Wall (Anthrax)

英文名字

Bacillus anthracis, Cell Wall (Anthrax)

供應(yīng)商

USBiological

產(chǎn)品貨號(hào)

215897

產(chǎn)品報(bào)價(jià)

￥1/5mg

產(chǎn)品說(shuō)明書(shū)

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產(chǎn)品新聞

背景資料

USBiological品牌是全球有名的抗原抗體和生化試劑供應(yīng)商，生產(chǎn)世界上種類最多的抗體，用于Western Blot、免疫沉淀、免疫熒光、免疫組化和流式細(xì)胞術(shù)等多種檢測(cè)方法。武漢艾美捷科技作為USBiological品牌中國(guó)區(qū)域總代理，是行業(yè)中少有的致力于服務(wù)客戶，幫助客戶，且擁有獨(dú)立的專業(yè)銷售團(tuán)隊(duì)、技術(shù)支持團(tuán)隊(duì)、市場(chǎng)營(yíng)銷團(tuán)隊(duì)、進(jìn)出口報(bào)關(guān)團(tuán)隊(duì)的高科技生物企業(yè)。可以為您提供及時(shí)的咨詢響應(yīng)，專業(yè)的產(chǎn)品和解決方案支持，穩(wěn)健快捷的交貨周期，優(yōu)質(zhì)放心的售后服務(wù)。我們致力于為您提供有價(jià)值的產(chǎn)品和服務(wù)，在意您的成功！

產(chǎn)品描述

Bacillus anthracis is the etiological agent of anthrax. Major virulence factors produced by Bacillus anthracis are the gamma-linked, poly-D-glutamic acid capsule and an exotoxin composed of three components, protective antigen (PA), lethal factor (LF), and edema factor (EF). These proteins are not toxic separately but act in binary combinations.?The complex of PA, the cell binding component, with LF, one of the enzymatic moieties, is termed “l(fā)ethal toxin” and can cause death.?PA and the enzymatic EF together cause skin edema. After secretion, PA is cleaved by membrane peptidases, allowing the 63kD carboxy terminal fragment to oligomerize to a heptamer.?Cleavage is an essential step in exposing the binding sites for EF and LF.?The assembled PA complex and associated LF or EF enters the cell through endocytosis.?PA mediates the transfer of LF and EF to the cytoplasm where these enzymes recognize and proteolyze their targets.?The LF component, a zinc-dependent metalloprotease, cleaves the mitogen-activated protein kinase kinase (MAPKK), impairing its function and thereby blocking the MAPK signaling pathway.?EF is a calmodulin-dependent adenylate cyclase which creates in the cell excess amounts of cyclic-AMP, resulting in edema.?Current research is focused on the development of an effective vaccine as well as screening for potent inhibitors of the LF enzymatic activity. Cell wall from B. anthracis is the insoluble component remaining after repeated extractions of the cell pellet. Source:Cell wall from B. anthracis AA Analysis:Contains 4.04nm amino acid/ug cell wallStorage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

產(chǎn)品形式

該產(chǎn)品為凍干粉形式。 May be suspended in water or buffer。The efficiency of suspension may be increased by sonication and the use of 0.5% TEA。

保存建議

接收到Bacillus anthracis, Cell Wall (Anthrax)產(chǎn)品后，置于-20°C溫度下保存。

其他

Usbiological公司是美國(guó)著名的抗體和生化試劑供應(yīng)商，生產(chǎn)世界上種類最多的抗體，用于Western Blot、免疫沉淀、免疫熒光、免疫組化和流式細(xì)胞術(shù)等多種檢測(cè)方法。Usbiological公司現(xiàn)已擁有超過(guò)50,19234種抗體、抗原和生化產(chǎn)品，為科研用戶提供了諸多超值選擇。

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。

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