NBD-Binding Peptide II, Cell Permeable (CTP-NBD, NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD)-NBD-Binding Peptide II, Cell Permeable (CTP-NBD, NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD)代理/參數(shù)/廠家-生化試劑-艾美捷科技有限公司

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中文名稱: NBD-Binding Peptide II, Cell Permeable (CTP-NBD, NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD)

英文名字: NBD-Binding Peptide II, Cell Permeable (CTP-NBD, NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD)

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產(chǎn)品描述: A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFa-stimulated NF-kB activity (IC50~50uM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents lkBa phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Formula:C123H197N47O32Molecular Weight:2846.2Solubility:H2O (50mg/ml)Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

保存建議: 接收到NBD-Binding Peptide II, Cell Permeable (CTP-NBD, NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD)產(chǎn)品后，置于-20°C溫度下保存。

其他: Usbiological公司是美國著名的抗體和生化試劑供應(yīng)商，生產(chǎn)世界上種類最多的抗體，用于Western Blot、免疫沉淀、免疫熒光、免疫組化和流式細(xì)胞術(shù)等多種檢測方法。Usbiological公司現(xiàn)已擁有超過50,19234種抗體、抗原和生化產(chǎn)品，為科研用戶提供了諸多超值選擇。