10Z-羥乙二胺(250 ug)產(chǎn)品是Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC?? = 6nM). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-β (GSK-3β) and CDK5/p35 in Alzheimer’s disease. Inhibitor of DNA damage checkpoint at G2 phase?(IC?? = 6 uM),?cyclin-dependent kinases?CDK1/cyclin B (IC?? = 22 nM),?CDK2/cyclin A (IC??= 70 nM), CDK2/cyclin E?(IC??= 40 nM), CDK4/cyclin D1 (IC?? = 600 nM), CDK5/p25 (IC?? = 28 nM),?GSK-3β (IC?? = 10 nM),?and?casein kinase 1?(CK1) (IC?? = 35 nM).?