依拉汀(1 mg)產品是Erastin is a selective antitumor agent that displays greater lethality in human tumour cells harbouring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to?mitochondrial volatage-dependent anion channels?(VDAC)?proteins,?more specifically on VDAC2?and?alters its gating. Erastin rapidly induces an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling.