皂素(500微克)產(chǎn)品是A fungal mycotoxin that inhibits the histone lysine methyltransferase (HKMT) SU(VAR)3-9 (IC?? = 0.8 uM). Inhibits other Lys9-specific HMTs, including G9a (IC?? = 2.5 uM) and DIM5 (IC?? = 3 uM). Selectivity for Lys9-HMTs is indicated by higher IC?? values (>90 uM) for Lys20-specific PRSET7, Lys27-specific EZH2, and Lys4-specific SET7/9.