BI-2536(25毫克)產(chǎn)品是BI-2536 is a potent, selective inhibitor of polo-like kinase 1 (PLK1) (IC?? = 0.83 nM). It blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC?? of 3.5 nM and 9.0 nM, respectively. BI-2536 potently causes a mitotic arrest and induces apoptosis in human cancer cell lines of diverse tissue origin.