LFM-A13(25毫克)產(chǎn)品是FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC??’s = 2.5 uM (recombinant BTK) and 17.2 uM (human BTK). It has also been shown to inhibit Polo-like kinase (PLK) (IC?? = 61 uM for human PLK3). It displays no activity (concentrations up to 278 uM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten tyrosine kinases.