NVP-BHG712(25毫克)產(chǎn)品是A potent, selective small-molecule inhibitor of the receptor tyrosine kinase EphB4 (ED?? = 25 nM). Displays selectivity for EphB4 over >40 other kinases in vitro, including FGFR3. NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.