RKI-1447(5毫克)產(chǎn)品是A highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC?? values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2). RKI-1447 suppresses ROCK-dependent signaling, cell morphology, anchorage-independent cell growth, migration invasion and in vivo growth of mammary tumors.