(±)-棉酚(50 mg)產(chǎn)品是Isolated from cotton seeds. It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of?P. falciparum?at low micromolar concentrations.?It inhibits aldose reductase (Ki?= 0.5 uM).Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations. Also acts as a non-selective competitive?inhibitor?of NADH binding to?LDH, with K(i) values of 1.9, 1.4, and 4.2 uM for?LDH-A4, -B4, and -C4, respectively.