IPA-3(5毫克)產(chǎn)品是IPA-3 is a cell-permeable allosteric inhibitor of PAK1 (tha p21-activated kinase 1) that is non-competitive with respect to ATP binding (IC???= 2.5 uM).?It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd?= 1.9 uM) and prevents binding to the upstream activator Cdc42. Potential anti-tumor agent.