MANF is a trophic factor for midbrain dopamine neurons?in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson’s disease (Lindholm et al., 2008, Voutilainen et al., 2009). When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta
應(yīng)用類型
ELISA, WB, IF, IHC
免疫原
Human MANF
來源宿主
兔
反應(yīng)性
Human MANF
保存建議
Storage:?Store at +4°C upon receipt. As product is (NH4)2SO4?precipitate, mix well by pipetting or vortexing prior use