G3BP抗體-G3BP Antibody （ATP-dependent DNA helicase VIII）代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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背景資料: G3BP1 （GTPase activating protein （SH3 domain） binding protein 1），also known as G3BP or HDH-VIII，is a ubiquitously expressed protein that localizes to the cytoplasm in proliferating cells and to the nucleus in non-proliferating cells. One of several DNA-unwinding enzymes，G3BP1 functions as a sequence-specific，phosphorylation-dependent helicase that unwinds partial RNA and DNA duplexes containing hanging 3’- or 5’- ends. G3BP1 uses magnesium as a cofactor and，in addition to its helicase activity，acts as an endoribonuclease that cleaves mRNA between adenine and cytosine residues at the 3’-UTR. An element of the Ras signaling pathway，G3BP1 binds to the SH3 domain of Ras GTPase-activating protein （Ras GAP） in proliferating cells，thereby regulating Ras signaling events in developing tissues. Due to its involvement in both DNA replication and signaling pathways within the cell，G3BP1 expression is implicated in the pathogenesis of several cancers，including esophageal squamous carcinoma.

保存建議: 提供的G3BP抗體產(chǎn)品為無(wú)色溶液形式，含有100 ug抗體.該產(chǎn)品濃度為0.5 mg/ml，溶解于包含有0.01 % BSA， 0.01 % 硫柳汞和50 % 甘油的PBS（pH 7.2）緩沖液中.請(qǐng)?jiān)谑盏皆揋3BP抗體產(chǎn)品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復(fù)凍融.

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