Furin is a ubiquitous protein located within the trans-Golgi network. It is found in many tissues and cell lines including MDCK,HeLa,HepG2 and NIH-3T3. Furin is a proprotein convertase that is responsible for the proteolytic maturation of many precursor proteins that are secreted from the constitutive secretory pathway
應(yīng)用類型
Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~95-110 kDa Furin/PACE. A splice variant (~60 kDa) can also be detected.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 779 of mouse Furin/PACE