20-HETE-d6 contains six deuterium atoms at the 16, 16 , 17, 17 , 18 and 18 positions. It is intended for use as an internal standard for the quantification of 20-HETE by GC- or LC-mass spectrometry. 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction. 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.
產(chǎn)品描述
20-HETE-d6 contains six deuterium atoms at the 16, 16 , 17, 17 , 18 and 18 positions. It is intended for use as an internal standard for the quantification of 20-HETE by GC- or LC-mass spectrometry.