中文名稱

【PGRN】人源細(xì)胞表達(dá)的再生大鼠顆粒蛋白前體（10 ug）

英文名字

Human CellExp Progranulin, Rat Recombinant

供應(yīng)商

Biovision

產(chǎn)品貨號(hào)

4735-10

產(chǎn)品報(bào)價(jià)

￥已停產(chǎn)

產(chǎn)品說明書

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購買方式

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產(chǎn)品新聞

背景資料

Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. Rat Recombinant Progranulin fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain purified by standard chromatographic techniques, containing 602 amino acids and having a molecular mass of ~65.0 kDa.

序列

人源細(xì)胞表達(dá)的重組大鼠顆粒蛋白前體蛋白產(chǎn)品，又稱Proepithelin; PEPI; PC Cell-derived Growth Factor.其對(duì)應(yīng)NCBI基因號(hào)為10116，對(duì)應(yīng)Accession號(hào)為P23785.

來源宿主

提供的【PGRN】人源細(xì)胞表達(dá)的重組大鼠顆粒蛋白前體產(chǎn)品的來源為人胚胎腎HEK293細(xì)胞重組表達(dá)重組表達(dá).

溶解建議

人源細(xì)胞表達(dá)的重組大鼠顆粒蛋白前體產(chǎn)品請(qǐng)按照說明書建議進(jìn)行溶解操作：Reconstitute in dH2O before use.

保存建議

在您收到艾美捷發(fā)出的【PGRN】人源細(xì)胞表達(dá)的重組大鼠顆粒蛋白前體產(chǎn)品后，建議將其置于-20°C保存.

其他

BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的Leader，BioVision在開發(fā)和研究細(xì)胞凋亡檢測(cè)分析、代謝檢測(cè)方面具有卓越的影響力.包括檢測(cè)各種檢測(cè)分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號(hào)轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質(zhì)、新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.

注意

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