LAMP-2抗體（C末端）-LAMP-2 Antibody （CT）（LAMP-2， Lysosome associated membrane protein 2）代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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背景資料: Autophagy，the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR （Target of rapamycin）. LAMP-2，a highly glycosylated protein associated with the lysosome，has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon’s disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.

應(yīng)用類型: Western Blot: 1 - 2 ug/ml， Immunocytochemistry: 10 ug/ml， ELISA. However， the optimal conditions should be determined individually.

免疫原: LAMP-2 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human LAMP-2.

反應(yīng)性: 經(jīng)檢測(cè)驗(yàn)證，可與人、小鼠種屬來(lái)源的LAMP-2抗體（C末端）蛋白發(fā)生免疫反應(yīng).

保存建議: 提供的LAMP-2抗體（C末端）產(chǎn)品為無(wú)色溶液形式，含有100 ug抗體.該產(chǎn)品濃度為1 mg/ml，溶解于包含有0.02 % 疊氮化鈉的PBS緩沖液中.請(qǐng)?jiān)谑盏皆揕AMP-2抗體（C末端）產(chǎn)品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復(fù)凍融.

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