Proprotein convertase subtilisin/kexin type 9 (PCSK9),is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR),inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
提供的PCSK9抗體產(chǎn)品為凍干粉末形式,含有100 ug抗體.該產(chǎn)品濃度為與批次相關(guān),溶解于包含有50 mM tris, 100 mM 甘氨酸, 海藻糖和0.05% 疊氮化鈉的凍干粉中.請(qǐng)?jiān)谑盏皆揚(yáng)CSK9抗體產(chǎn)品后,將其置于-20 °C冷凍保存,建議分裝使用以避免反復(fù)凍融.