Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade substances within the extracellular matrix. The MMP family includes six different groups of enzymes: collagenases,gelatinases,stromelysins,transmembrane MMPs,matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs,plasmins as well as other factors activate MMPs. MMPs are thought to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP1 cleaves collagens of types I,II,III,VII and X.? MMP1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction.
應(yīng)用類型
Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually.
免疫原
E. coli-expressed recombinant human MMP-1 (Cat.# 7781-10)
來源宿主
兔
反應(yīng)性
經(jīng)檢測驗證,可與人種屬來源的MMP-1蛋白 發(fā)生免疫反應(yīng).
保存建議
提供的MMP-1抗體 產(chǎn)品為100 ug 無色溶液,其濃度為0.5 mg/ml,溶解于包含有30%甘油, 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該MMP-1抗體 產(chǎn)品置于-20 ℃冷凍保存,建議分裝使用以避免反復(fù)凍融.