UCHL3抗體-UCHL3 Antibody （Ubiquitin carboxyl-terminal hydrolase isozyme L3， Ubiquitin thioesterase L3， UCH-L3， Ubiquitin C-terminal hydrolase L3）代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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中文名稱: UCHL3抗體

英文名字: UCHL3 Antibody （Ubiquitin carboxyl-terminal hydrolase isozyme L3， Ubiquitin thioesterase L3， UCH-L3， Ubiquitin C-terminal hydrolase L3）

供應(yīng)商: Biovision

產(chǎn)品貨號: 6128-50

產(chǎn)品報價: ￥已停產(chǎn)

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背景資料: Protein ubiquitination and Deubiquitination are reversible processes catalyzed by ubiquitinating enzymes （UBEs） and deubiquitinating enzymes （DUBs）. DUBs are categorized into 5 subfamilies: USP，UCH，OTU，MJD，and JAMM. UCHL1，UCHL3，UCHL5/UCH37，and BRCA-1-associated protein-1 （BAP1） belong to the UCH family of DUBs，which all possess a conserved catalytic domain （UCH domain） of about 230 amino acids. Although UCHL1 and UCHL3 are the most closely related UCH family members with about 53% identity，their biochemical properties differ in that UCHL1 binds monoubiquitin and UCHL3 shows dual specificity toward both ubiquitin （Ub） and NEDD8，a Ub-like molecule. UCHL3 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 has a 10-fold preference for Arg and Lys at position P3. It deubiquitinates ENAC in the apical compartments，thereby regulating apical membrane recycling. UCHL3 indirectly increases the phosphorylation of IGFIR，AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal，skeletal muscle and germ cell maintenance. UCHL3 may be involved in working memory.UCHL3 possesses 52% amino acid identity with UCHL1 and is uniformly expressed in all tissues，including the brain. The activity of UCHL3 is more than 200-fold higher than UCH-L1，as assessed with a fluorogenic ubiquitin substrate.

應(yīng)用類型: Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 ug/mL

免疫原: Recombinant full length protein

來源宿主: 雞

反應(yīng)性: 經(jīng)檢測驗證，可與人種屬來源的UCHL3蛋白發(fā)生免疫反應(yīng).

保存建議: 提供的UCHL3抗體產(chǎn)品為無色溶液形式，含有50 ug抗體.該產(chǎn)品濃度為與批次相關(guān)，溶解于包含有10% 甘油的PBS緩沖液中.請在收到該UCHL3抗體產(chǎn)品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復凍融.

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學公司的Leader，BioVision在開發(fā)和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關(guān)特色抗體、重組蛋白及細胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉(zhuǎn)導、干細胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質(zhì)、新的細胞生物學研究工具而不斷擴大產(chǎn)品及服務(wù)質(zhì)量.