USP4抗體-USP4 Antibody （Deubiquitinating enzyme 4， Ubiquitin carboxyl-terminal hydrolase 4， Ubiquitin-specific-processing， protease 4， Ubiquitin thioesterase 4， Ubiquitous nuclear protein代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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英文名字: USP4 Antibody （Deubiquitinating enzyme 4， Ubiquitin carboxyl-terminal hydrolase 4， Ubiquitin-specific-processing， protease 4， Ubiquitin thioesterase 4， Ubiquitous nuclear protein

背景資料: Ubiquitinating enzymes （UBEs） catalyze protein ubiquitination，a reversible process countered by deubiquitinating enzyme （DUB） action. Five DUB subfamilies are recognized，including the USP，UCH，OTU，MJD，and JAMM enzymes. USP4 was originally identified during a survey of murine genes near the Mpv20 retroviral insertion site and initially referred to as Ubiquitous Nuclear Protein （UNP）. Analysis of the mouse cDNA originally nidentified Usp4/Unp as a proto-oncogene related to the human tre-2/tre-17/USP6 proto-oncogene. Usp4/Unp was subsequently observed to contain the conserved Cys and His boxes of the UBP family as well as DUB activity. In a study of primary lung tumor tissue，it was observed that the human homolog of Usp4，USP4/UNPH，had elevated gene expression levels in small cell tumors and adenocarcinomas of the lung，suggesting a causative role for USP4 in neoplasia. Another recent study demonstrated overexpression of USP4 in several types of human cancer and that USP4 positively contributes to cell transformation by negatively regulating p53 levels. Both murine and human USP4 have been shown to interact with the Rb family of tumor suppressor proteins，providing additional mechanistic evidence of a role for USP4 in cellular transformation.

應用類型: Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 ug/mL

保存建議: 提供的USP4抗體產品為無色溶液形式，含有50 ug抗體.該產品濃度為與批次相關，溶解于包含有10% 甘油的PBS緩沖液中.請在收到該USP4抗體產品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復凍融.

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