USP8抗體-USP8 Antibody （Deubiquitinating enzyme 8， hUBPy， HumORF8， KIAA0055， MGC129718， Ubiquitin carboxyl-terminal hydrolase 8， Ubiquitin-specific processing protease 8， Ubiquitin thioest代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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英文名字: USP8 Antibody （Deubiquitinating enzyme 8， hUBPy， HumORF8， KIAA0055， MGC129718， Ubiquitin carboxyl-terminal hydrolase 8， Ubiquitin-specific processing protease 8， Ubiquitin thioest

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背景資料: Ubiquitinating enzymes （UBEs） catalyze protein ubiquitination，a reversible process countered by deubiquitinating enzyme （DUB） action. Five DUB subfamilies are recognized，including the USP，UCH，OTU，MJD，and JAMM enzymes. The deubiquitinating enzyme ubiquitin-specific protease 8 （USP8/UBPy） is a cysteine protease belonging to the USP/UBP subfamily. Research studies have shown that USP8 is an essential growth-regulated enzyme indispensible for cell proliferation and survival. Indeed，conditional knock-out of murine USP8 was shown to promote a dramatic loss in expression of receptor tyrosine kinases，including EGFR，ErbB3，and c-Met. In agreement with these findings，USP8 inactivation leads to enhanced ubiquitination of ligand-activated EGFR. Furthermore，phosphorylation of USP8 at Ser680 results in its binding of 14-3-3，catalytic inactivation，and reduced EGFR deubiquitination. It appears as though USP8，in conjunction with components of the ESCRT-0 complex，plays an integral role in the early endosomal sorting machinery that functions to protect EGFR from lysosomal degradation.

應用類型: Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 ug/mL

保存建議: 提供的USP8抗體產(chǎn)品為無色溶液形式，含有50 ug抗體.該產(chǎn)品濃度為與批次相關(guān)，溶解于包含有10% 甘油的PBS緩沖液中.請在收到該USP8抗體產(chǎn)品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復凍融.

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學公司的Leader，BioVision在開發(fā)和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關(guān)特色抗體、重組蛋白及細胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉(zhuǎn)導、干細胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質(zhì)、新的細胞生物學研究工具而不斷擴大產(chǎn)品及服務(wù)質(zhì)量.