USP14抗體-USP14 Antibody （Deubiquitinating enzyme 14， TGT， Ubiquitin carboxyl-terminal hydrolase 14， Ubiquitin-specific processing protease 14， Ubiquitin thioesterase 14， Ubiquitin-specific代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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英文名字: USP14 Antibody （Deubiquitinating enzyme 14， TGT， Ubiquitin carboxyl-terminal hydrolase 14， Ubiquitin-specific processing protease 14， Ubiquitin thioesterase 14， Ubiquitin-specific

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背景資料: Ubiquitinating enzymes （UBEs） catalyze protein ubiquitination，a reversible process countered by deubiquitinating enzyme （DUB） action. Five DUB subfamilies are recognized，including the USP，UCH，OTU，MJD，and JAMM enzymes. In humans，there are three proteasomal DUBs: PSMD14 （POH1/RPN11），UCH37 （UCH-L5），and Ubiquitin-Specific Protease 14，which is also known as the 60 kDa subunit of tRNA-guanine transglycosylase （USP14/TGT60 kDa）. USP14 is recruited to the proteasome through its reversible association with the PSMD2 （S2/hRPN1） subunit of the 19S regulatory particle. Whereas PSMD14 appears to promote substrate degradation，USP14 is thought to antagonize substrate degradation. While the underlying mechanism for the opposing roles of these two proteasomal DUBs is still uncertain，it is thought that USP14 removes ubiquitin from substrate upon docking of the substrate with the 26S proteasome. Furthermore，USP14 trims ubiquitin residues from the distal end of the polyubiquitin chain，thus decreasing the affinity of the chain for the ubiquitin receptors of the proteasome，and allowing for enhanced substrate stability. Studies have elucidated a physiologic role for USP14 in regulating synaptic activity in mammals. Research studies have shown that targeting this activity with small molecule inhibitors has potential benefits for the treatment of neurodegenerative diseases and cancer.

應(yīng)用類型: Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 ug/mL

保存建議: 提供的USP14抗體產(chǎn)品為無(wú)色溶液形式，含有50 ug抗體.該產(chǎn)品濃度為與批次相關(guān)，溶解于包含有10% 甘油的PBS緩沖液中.請(qǐng)?jiān)谑盏皆揢SP14抗體產(chǎn)品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復(fù)凍融.

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