This gene encodes a nuclear protein?which is involved in?cell cycle regulation. The encoded protein?is a ubiquitin ligase capable?of ubiquinating PCNP?(PEST-containing nuclear protein),and together they may?play?a role?in?tumorigenesis. The encoded protein?contains an NIRF_N domain,a PHD finger,a set- and ring associated (SRA) domain,and a RING finger domain and several?of these domains have been shown to be essential for the regulation of cell?proliferation. This protein?may also have a role in?intranuclear degradation of polyglutamine aggregates. Alternative splicing results in?multiple transcript?variants,some?of which are non-protein?coding. [Provided by RefSeq,F(xiàn)eb 2012].