EHMT2抗體-EHMT2 Antibody （BAT8， C6orf30， DKFZp686H08213， FLJ35547， G9A， KMT1C， NG36， NG3）代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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中文名稱: EHMT2抗體

英文名字: EHMT2 Antibody （BAT8， C6orf30， DKFZp686H08213， FLJ35547， G9A， KMT1C， NG36， NG3）

供應(yīng)商: Biovision

產(chǎn)品貨號(hào): 6152-100

產(chǎn)品報(bào)價(jià): ￥已停產(chǎn)

產(chǎn)品說(shuō)明書(shū): 點(diǎn)擊查看

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背景資料: G9a，also known as Euchromatic histone-lysine N-methyltransferase 2 （EHMT2），is a member of a family of histone lysine methyltransferases. Recombinant G9a can mono-，di-?and tri-methylate histone H3 on Lys9 and Lys27 in?vitro. However，in?vivo G9a forms a complex with GLP，a G9a-related histone methyltransferase，and together these proteins?function as the major euchromatic histone H3 Lys9 mono- and di-methyltransferases，creating transcriptionally repressive marks that facilitate gene silencing. G9a methylates itself on Lys165，a modification that regulates?the association of HP1?repressor proteins?with the G9a/GLP?complex. The G9a/GLP complex also contains Wiz，a zinc finger protein?that is required for G9a/GLP?hetero-dimerization and complex stability. Wiz contains two CtBP?co-repressor binding sites，which mediate?the association of the G9a/GLP with the CtBP?co-repressor complex. In addition，G9a and GLP?are components of other large transcriptional?co-repressor complexes，such as those involving E2F6 and CDP/cut. G9a interacts with DNMT1，and both proteins?are required for methylation of DNA and histone H3 （Lys9） at replication foci，providing a functional?link?between histone H3 Lys9 and CpG?methylation during DNA?replication. G9a activity is critical for meiotic prophase progression，as mutant mice deficient in germ?line G9a show a large loss of mature gametes. In addition，G9a facilitates increased global?levels of di-methyl?histone H3 （Lys9） during hypoxic stress and increased G9a expression is associated with hepatocellular carcinoma.

應(yīng)用類型: Western blot: 1:500 – 1:2000， IHC: 1:50 – 1:200.

免疫原: Recombinant protein of human EHMT2

來(lái)源宿主: 兔

反應(yīng)性: 經(jīng)檢測(cè)驗(yàn)證，可與人、小鼠、大鼠種屬來(lái)源的EHMT2蛋白發(fā)生免疫反應(yīng).

保存建議: 提供的EHMT2抗體產(chǎn)品為無(wú)色溶液形式，含有100 ug抗體.該產(chǎn)品濃度為1 mg/ml，溶解于包含有50% 甘油和0.02%疊氮化鈉的PBS緩沖液（pH 7.3）中.請(qǐng)?jiān)谑盏皆揈HMT2抗體產(chǎn)品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復(fù)凍融.

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的Leader，BioVision在開(kāi)發(fā)和研究細(xì)胞凋亡檢測(cè)分析、代謝檢測(cè)方面具有卓越的影響力.包括檢測(cè)各種檢測(cè)分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號(hào)轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國(guó)總代理以及中國(guó)區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質(zhì)、新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.