SMARCA4抗體-SMARCA4 Antibody （BAF190， BRG1， FLJ39786， SNF2， SNF2-BETA， SNF2L4， SNF2LB， SWI2， hSNF2b.）代理/參數/廠家-二抗-艾美捷科技有限公司

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英文名字: SMARCA4 Antibody （BAF190， BRG1， FLJ39786， SNF2， SNF2-BETA， SNF2L4， SNF2LB， SWI2， hSNF2b.）

背景資料: The modulation of chromatin?structure is an essential?component in?the regulation of transcriptional?activation and repression. Modifications can be made by at least two evolutionarily conserved strategies，through the disruption of histone-DNA?contacts by ATP-dependent chromatin?remodelers，or by histone tail modifications including methylation and acetylation. One of the four classes of ATP-dependent histone remodelers is the SWI/SNF complex，the central catalytic subunit of which is Brg1 or the highly related protein?hBRM. This SWI/SNF complex contains?varying subunits but its association with either Brg1 or hBRM remains constant. SWI/SNF complexes have been shown to regulate?gene activation，cell growth，the cell cycle?and differentiation. Brg1/hBRM?has been shown to regulate?transcription through enhancing transcriptional?activation of glucocorticoid?receptors. Although usually associated with transcriptional?activation，Brg1/hBRM?have also been found in?complexes associated with transcriptional?repression including with HDACs，Rb and Tif1B. Brg1/hBRM?plays a vital role in the regulation of gene transcription during early mammalian embryogenesis. In addition，Brg1/hBRM?also plays a role?as a tumor suppressors and Brg1 is mutated in?several?tumor cell?lines.

保存建議: 提供的SMARCA4抗體產品為無色溶液形式，含有100 ug抗體.該產品濃度為1 mg/ml，溶解于包含有50% 甘油和0.02%疊氮化鈉的PBS緩沖液（pH 7.3）中.請在收到該SMARCA4抗體產品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復凍融.

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學公司的Leader，BioVision在開發(fā)和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關特色抗體、重組蛋白及細胞因子和酶等多種產品，以及其他創(chuàng)新的研究工具.其產品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉導、干細胞研究等領域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質、新的細胞生物學研究工具而不斷擴大產品及服務質量.