S100A8抗體（克隆號IMG48M7C7）-S100A8 Antibody （Clone IMG48M7C7）（Calgranulin-A， Calprotectin L1L subunit， Cystic fibrosis antigen， CFAG， Leukocyte L1 complex light chain， Migration inhibitory factor-related pro代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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中文名稱: S100A8抗體（克隆號IMG48M7C7）

英文名字: S100A8 Antibody （Clone IMG48M7C7）（Calgranulin-A， Calprotectin L1L subunit， Cystic fibrosis antigen， CFAG， Leukocyte L1 complex light chain， Migration inhibitory factor-related pro

供應(yīng)商: Biovision

產(chǎn)品貨號: 6196-100

產(chǎn)品報價: ￥已停產(chǎn)

產(chǎn)品說明書: 點擊查看

購買方式: 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868.

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背景資料: S100A8 is a low-molecular weight member of the S100 family of calcium-binding protein which promotes tumorigenesis. It promotes cell migration and invasion through p38 MAP dependent NF-kappaB activation leading to an increase of MMP2 and MMP12 in gastric cancer. The phagocyte-specific Ca2+-binding S100A8 protein has been proposed as an essential regulator of the plasma membrane NADPH oxidase activity. It is abundantly expressed in the cytosol of neutrophils and is able to form Ca2+-dependent heterocomplexes，with heterotetramers being a probable prerequisite for its biological activities in myeloid cells. S100A8 and S100A9 have been proposed as essential regulators that exert their role through interactions with NADPH oxidase subunits. S100A8 and S100A9 are generally considered proinflammatory. Whereas hypohalous acids generated by activated phagocytes promote novel modifications in murine S100A8 but modifications to human S100A8 are undefined and there is no evidence that these proteins scavenge oxidants in human disease. Oxidized S100A8 was prominent in lungs from patients with asthma and significantly elevated in sputum compared to controls. Results have broad implications for conditions under which hypohalous acid oxidants are generated by activated phagocytes. Identification in human disease of the novel S100A8 Cys derivatives typical of those generated in vitro strongly supports the notion that S100A8 contributes to antioxidant defense during oxidative stress.

應(yīng)用類型: IHC （P）: use antibody at 2 ug/ml， Western blot analysis: 0.5-5 ug/ml.

免疫原: Amino acids 2-93 of human S100A8

來源宿主: 小鼠

反應(yīng)性: 經(jīng)檢測驗證，可與人、小鼠種屬來源的S100A8抗體（克隆號IMG48M7C7）蛋白發(fā)生免疫反應(yīng).

保存建議: 提供的S100A8抗體（克隆號IMG48M7C7）產(chǎn)品為無色溶液形式，含有100 ug抗體.該產(chǎn)品濃度為0.5 mg/ml，溶解于包含有0.05% BSA和0.05%疊氮化鈉的PBS緩沖液中.請在收到該S100A8抗體（克隆號IMG48M7C7）產(chǎn)品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復(fù)凍融.

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的Leader，BioVision在開發(fā)和研究細(xì)胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質(zhì)、新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.