USP8抗體-USP8 Antibody代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

PRODUCT CENTER

二抗

產(chǎn)品中心

當(dāng)前位置：首頁(yè) > 產(chǎn)品中心 > 免疫學(xué)產(chǎn)品 > 二抗

購(gòu)買方式: 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868.

背景資料: Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination，a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized，including the USP，UCH，OTU，MJD，and JAMM enzymes. The deubiquitinating enzyme ubiquitin-specific protease 8 (USP8/UBPy) is a cysteine protease belonging to the USP/UBP subfamily. Research studies have shown that USP8 is an essential growth-regulated enzyme indispensible for cell proliferation and survival. Indeed，conditional knock-out of murine USP8 was shown to promote a dramatic loss in expression of receptor tyrosine kinases，including EGFR，ErbB3，and c-Met. In agreement with these findings，USP8 inactivation leads to enhanced ubiquitination of ligand-activated EGFR. Furthermore，phosphorylation of USP8 at Ser680 results in its binding of 14-3-3，catalytic inactivation，and reduced EGFR deubiquitination. It appears as though USP8，in conjunction with components of the ESCRT-0 complex，plays an integral role in the early endosomal sorting machinery that functions to protect EGFR from lysosomal degradation.

免疫原: Synthetic peptide corresponding to an internal sequence of human USP 8 (BV-L43)

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的Leader，BioVision在開(kāi)發(fā)和研究細(xì)胞凋亡檢測(cè)分析、代謝檢測(cè)方面具有卓越的影響力.包括檢測(cè)各種檢測(cè)分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號(hào)轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國(guó)總代理以及中國(guó)區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質(zhì)、新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.