ANGPT2抗體（C末端）-ANGPT2 Antibody （CT）（ANGPT2； Angiopoietin-2.）代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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中文名稱: ANGPT2抗體（C末端）

英文名字: ANGPT2 Antibody （CT）（ANGPT2； Angiopoietin-2.）

供應(yīng)商: Biovision

產(chǎn)品貨號(hào): 6759-100

產(chǎn)品報(bào)價(jià): ￥已停產(chǎn)

產(chǎn)品說(shuō)明書(shū): 點(diǎn)擊查看

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背景資料: Angiopoietin-2，also known as ANGPT2，AGPT2，ANG2，and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development，but it is restricted postnatally to highly angiogenic tissues such as the placenta，ovaries，and uterus. It is particularly abundant in vascular endothelial cells （EC） where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 （Ang1） are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor，although it can also induce EC death and vessel regression. Upon its release from quiescent EC，it regulates vascular remodeling by promoting EC survival，proliferation，and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling，and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC，which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2，and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes have been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling，induces endothelial cell apoptosis，and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of sub ventricular zone progenitor cells.

應(yīng)用類型: Western blot: ~1:1000， IHC: ~1:50-1:100， FACS: ~1:10–1:50.

免疫原: This ANGPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human ANGPT2.

來(lái)源宿主: 兔

反應(yīng)性: 經(jīng)檢測(cè)驗(yàn)證，可與人和小鼠種屬來(lái)源的ANGPT2抗體（C末端）蛋白發(fā)生免疫反應(yīng).

保存建議: 提供的ANGPT2抗體（C末端）產(chǎn)品為無(wú)色溶液形式，含有100 ul抗體.該產(chǎn)品濃度為與批次相關(guān)，溶解于包含有0.09% （W/V）疊氮化鈉的PBS緩沖液中.請(qǐng)?jiān)谑盏皆揂NGPT2抗體（C末端）產(chǎn)品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復(fù)凍融.

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的Leader，BioVision在開(kāi)發(fā)和研究細(xì)胞凋亡檢測(cè)分析、代謝檢測(cè)方面具有卓越的影響力.包括檢測(cè)各種檢測(cè)分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號(hào)轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國(guó)總代理以及中國(guó)區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質(zhì)、新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.