The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and,more specifically,is closely related to the platelet derived growth factor receptor (PDGFR). c-Kit,the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene (v-Kit),encodes a transmembrane receptor. c-Kit regulates a variety of biological responses including chemotaxis,cell proliferation,apoptosis,and adhesion. c-Kit is also identical with the product of the W locus in mice and,as such,is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and is encoded at the murine steel (SI) locus. Kit is the human homolog of the proto-oncogene c-Kit. Mutations in Kit are integral for tumor growth and progression in various cancers.
應用類型
WB: 1:1000, IHC: 1:10 – 1:50, IF: 1:10 – 1:50.
免疫原
This c-KIT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-40 amino acids from the N-terminal region of human c-KIT.