PD-1/PDCD1抗體-PD-1/PDCD1 Antibody [PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l]代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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背景資料: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1，is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells，B cells，macrophages，myeloid cells and a subset of thymocytes. PD-1 has two ligands，PD-L1 and PD-L2，which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines，including PA1 myeloma，P815 mastocytoma，and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1，IL-4，IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition，coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro，treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion.

保存建議: 提供的PD-1/PDCD1抗體為無色溶液形式，產(chǎn)品濃度為與批次相關(guān)，溶解于包含有100 mM glycine與海藻糖的50 mM Tris緩沖液（pH 7.0）.請?jiān)谑盏皆揚(yáng)D-1/PDCD1抗體產(chǎn)品后，將其置于-20 °C冷凍保存，建議分裝使用以避免反復(fù)凍融.

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的Leader，BioVision在開發(fā)和研究細(xì)胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質(zhì)、新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.