Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin,kallikrein,plasmin and trypsin. It is present in blood and in most tissues,with a high concentration in lung,inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets,Aprotinin reduces glycoprotein loss (e.g.,GpIb,GpIIb/IIIa),while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins. Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids arranged in a single polypeptide chain,cross-linked by three disulfide bridges.
應(yīng)用類型
Western blot
免疫原
Bovine Aprotinin (Cat # 4690)
來源宿主
Rabbit
反應(yīng)性
Bovine. Predicted cross reactivity with human and mouse samples.