- 中文名稱
CAY10416 (50 mg)
- 英文名字
- CAY10416, 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole
- 供應(yīng)商
- Cayman
- 產(chǎn)品貨號(hào)
- 70635-50
- 產(chǎn)品報(bào)價(jià)
- ￥21070/50 mg
- 產(chǎn)品說明書
- 點(diǎn)擊查看
- 購(gòu)買方式
- 產(chǎn)品新聞
- 背景資料
- Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 uM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC50 value of 83 uM.
- 產(chǎn)品描述
- CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively.{10003} The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 uM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC50 value of 83 uM.
- 產(chǎn)品形式
- 保存建議
- -20
- 其他
- Cayman Chemical
- 注意
-
該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說明書為準(zhǔn)。下單前，請(qǐng)瀏覽說明書確認(rèn)。
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