【GDNF】重組大鼠膠質源性神經(jīng)營養(yǎng)因子（10 ug）-GDNF, rat recombinant代理/參數(shù)/廠家-重組蛋白-艾美捷科技有限公司

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背景資料: GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide linked homodimer, of two 15.0 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

序列: 重組大鼠膠質源性神經(jīng)營養(yǎng)因子蛋白產(chǎn)品，又稱Glial-Derived Neurotrophic Factor, ATF-1.其對應NCBI基因號為25453，對應Accession號為Q07731.

溶解建議: 重組大鼠膠質源性神經(jīng)營養(yǎng)因子產(chǎn)品請按照說明書建議進行溶解操作：Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

保存建議: 在您收到艾美捷發(fā)出的【GDNF】重組大鼠膠質源性神經(jīng)營養(yǎng)因子產(chǎn)品后，建議將其置于-20°C保存.

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