EPIT is a selective, competitive inhibitor of nNOS having a Ki of 0.32 uM for the purified human enzyme. EPIT exhibits 115-fold and 29-fold selectivity for nNOS compared to iNOS and eNOS, respectively. It exhibits reduced inhibitory potency in whole-cell assays, possibly due to reduced intracellular uptake.
產(chǎn)品描述
EPIT is a selective, competitive inhibitor of nNOS having a Ki of 0.32 uM for the purified human enzyme. EPIT exhibits 115-fold and 29-fold selectivity for nNOS compared to iNOS and eNOS, respectively. It exhibits reduced inhibitory potency in whole-cell assays, possibly due to reduced intracellular uptake.{5065}