Oleic acid-d17 contains 17 deuterium atoms at the 11, 11 , 12, 12 , 13, 13 , 14, 14 , 15, 15 , 16, 16 , 17, 17 , 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-mass spectrometry. Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 ug/ml. fMLF-induced neutrophil aggregation and degranulation is inhibited by 55% and 68%, respectively, using 5 uM oleic acid. This inhibition is comparable to that observed using arachidonic acid under the same conditions. Oleic acid, whether applied extracellularly (EC50 = ~60 uM) to human platelets or released from membrane phospholipids, causes an increase in intracellular calcium levels.
產(chǎn)品描述
An internal standard for the quantification of oleic acid by GC- or LC-MS