HMGB1抗體-HMGB1 Antibody代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

PRODUCT CENTER

二抗

產(chǎn)品中心

當(dāng)前位置：首頁 > 產(chǎn)品中心 > 免疫學(xué)產(chǎn)品 > 二抗

購買方式: 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868.

背景資料: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication，transcription，chromatin remodeling，V(D)J recombination，DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses，and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA，nucleosomes，IL-1 beta，CXCL12，AGER isoform 2/sRAGE，lipopolysaccharide (LPS) and lipoteichoic acid (LTA)，and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine，disulfide HMGB1 (actively secreted) as a cytokine，and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance.

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的Leader，BioVision在開發(fā)和研究細(xì)胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供優(yōu)質(zhì)、新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.