抗XRCC3抗體-Anti-XRCC3 Antibody代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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背景資料: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA，thought to repair chromosomal fragmentation，translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage，CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

免疫原: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human XRCC3

保存建議: 艾美捷提供的抗XRCC3抗體產(chǎn)品，請(qǐng)將該產(chǎn)品置于-20oC冷凍保存，建議分裝使用以避免反復(fù)凍融。

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