Regulates CDK7,the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1,CDK2,CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A),allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
應用類型
WB, IP
免疫原
Recombinant human Cyclin H protein fragments expressed in E.coli
來源宿主
提供的抗細胞周期蛋白H抗體(1H9-D3-E11)Anti-Cyclin H Antibody (1H9-D3-E11)產品,該來源宿主查看產品說明書。