Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance,since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels,while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4,an essential molecule in the hexakisphosphate (InsP6) pathway.
應(yīng)用類型
WB
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ITPK1