Recognizes a protein of 39 kDa,which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation,cytokinesis,protein localization to the centromere and kinetochore,correct microtubule-kinetochore attachment,and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma,astrocytoma,seminoma and carcinomas of the colon,prostate,endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
應用類型
FC, IF, WB
免疫原
Recombinant human Aurora B protein fragment (aa 89-251)
來源宿主
提供的抗Aurora B抗體(AURKB/1521)Anti-Aurora B Antibody (AURKB/1521)產(chǎn)品,該來源宿主查看產(chǎn)品說明書。