抗HMGB1單克隆抗體（克隆：ABM2E44）-Anti-HMGB1Monoclonal Antibody (Clone: ABM2E44)代理/參數(shù)/廠家-二抗-艾美捷科技有限公司

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背景資料: HMGB1 (High-mobility group protein B1) is a 25 kDa non-histone chromatin protein，secreted by immune cells throughnleaderless secretory pathway. HMGB1 supports transcription and also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. The presence of HMGB1 in the nucleus depends on posttranslational modifications. When the protein is not acetylated，it stays in the nucleus，but hyperacetylation on lysine residues causes it to translocate into the cytosol. HMGB1 has the ability to bend DNA in order to facilitate binding of other proteins to the DNA. HMGB1 has one important role in V(D)J recombination where act as a cofactor of the RAG complex. HMGB1 stimulates a plethora of cellular responses like inflammation，attracting inflammatory cells，recruiting stem cells and promoting their proliferation. HMGB1 is highly expressed in human kidney，tonsils，adipose tissue，adrenal cortex and amniotic fluid.

免疫原: A partial length recombinant HMGB1 protein (amino acids 1- 200) was used as the immunogen

來源宿主: 提供的抗HMGB1單克隆抗體（克隆：ABM2E44）Anti-HMGB1Monoclonal Antibody (Clone: ABM2E44)產(chǎn)品，該來源宿主查看產(chǎn)品說明書。

保存建議: 艾美捷提供的抗HMGB1單克隆抗體（克隆：ABM2E44）產(chǎn)品，請將該產(chǎn)品置于4°C冷凍保存，建議分裝使用以避免反復(fù)凍融。

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