The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation,cytokinesis,protein localization to the centromere and kinetochore,correct microtubule-kinetochore attachment,and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma,astrocytoma,seminoma and carcinomas of the colon,prostate,endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
應(yīng)用類型
WB, IHC
免疫原
A peptide corresponding to the C-terminus of human Aurora kinase B
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