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中文名稱(chēng)

針對(duì)扎伊爾埃博拉病毒 GP 蛋白的人單克隆 scFv-Fc 抗體

英文名字
Human monoclonal scFv-Fc antibody to Zaire Ebolavirus GP protein
供應(yīng)商
Icosagen
產(chǎn)品貨號(hào)
A2-101-100
產(chǎn)品報(bào)價(jià)
￥詢(xún)價(jià)/100ug   ￥500ug   ￥1mg
產(chǎn)品說(shuō)明書(shū)
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產(chǎn)品新聞
背景資料
GP1 is responsible for binding to the receptors on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). GP2 acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. Mediates activation of primary macrophages. At terminal stages of the viral infection, when its expression is high, GP1,2 down-modulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates integrins ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. GP1,2 alters the cellular recycling of the dimer alpha-V/beta-3 via a dynamin-dependent pathway. Decrease in the host cell surface expression of various adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during Ebola virus infection (cytotoxicity). (Ebola GP1 and 2 functions, UniProt).
應(yīng)用類(lèi)型
ELISA, WB, IF
免疫原
Ebolavirus GP protein
來(lái)源宿主
單克隆：兔 scFv、人 Fc
反應(yīng)性
Zaire Ebolavirus GP protein
保存建議
Store at -20…-70°C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles
其他
Icosagen AS成立于1999年，總部位于愛(ài)沙尼亞，提供一系列現(xiàn)成產(chǎn)品，如抗體、蛋白質(zhì)、ELISA試劑盒等，以及天然橡膠過(guò)敏原檢測(cè)和食品質(zhì)量控制領(lǐng)域的質(zhì)量控制服務(wù)。產(chǎn)品涵蓋的應(yīng)用領(lǐng)域有：神經(jīng)生物學(xué)，病毒學(xué)，心臟標(biāo)志物，細(xì)胞因子，炎癥，過(guò)敏原等。Icosagen提供用于診斷和研究的重組抗體和抗原。Icosagen將現(xiàn)代重組技術(shù)和20年的制藥經(jīng)驗(yàn)引入診斷領(lǐng)域，以開(kāi)發(fā)和生產(chǎn)高質(zhì)量的試劑。利用Icosagen的專(zhuān)利系列，開(kāi)發(fā)和生產(chǎn)高親和力和特異性的單克隆和多克隆抗體。Icosagen已通過(guò)ISO 9001:2015認(rèn)證，并遵循GLP指南。
注意
該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。
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