Proglucagon, a 158 amino acid polypeptide, is synthesized in the pancreatic alpha cells and the intestinal L-cells1. Its post-translational processing in the pancreas leads to GRPP, Glucagon, IP-1 and MPGF. While in the intestines, the post-translational process leads to Glicentin, Oxyntomodulin, GLP-1, IP-2 and GLP-2.2 Analogs and agonists of these proglucagon factors are used in the treatment and management of Type-1 and Type-2 diabetes and prevention of cardiovascular complications associated with diabetes.
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Jacques Philippe, Svetlana Mojsov, Daniel J. Drucker, Joel F. Habener., Proglucagon Processing in a Rat Islet Cell Line Resembles Phenotype of Intestine Rather than Pancreas, Endocrinology, Volume 119, Issue 6, 1 December 1986, Pages 2833–2839.
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Raffort, J., Lareyre, F., Massalou, D., Fénichel, P., Pana?a-Ferrari, P., & Chinetti, G. (2017). Insights on glicentin, a promising peptide of the proglucagon family. Biochemia medica, 27(2), 308–324.
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產(chǎn)品描述
The Proglucagon Enzyme Linked Immunosorbent Assay (ELISA) kit provides materials for the quantitative measurement of Proglucagon in human plasma and other biological fluids. No detectable cross-reactivity to Glucagon, GLP-1, GLP-2, Oxyntomodulin, GRPP, MPGF-1, MPGF-2, Insulin, C-Peptide, or Thyroglobulin.
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