GIP，完整 ELISA-GIP, Intact ELISA代理/參數(shù)/廠家-ELISA試劑盒-艾美捷科技有限公司

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中文名稱: GIP，完整 ELISA

英文名字: GIP, Intact ELISA

供應商: Ansh Labs

產(chǎn)品貨號: AL-1022

產(chǎn)品報價: ￥詢價/96wellmicrotiter

產(chǎn)品說明書: 點擊查看

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背景資料: Glucose-dependent insulinotropic polypeptide (GIP) (also known as gastric inhibitory polypeptide) is an incretin hormone produced in the upper gut and secreted to the circulation in response to the ingestion of foods, especially fatty foods(1). It is a peptide hormone consisting of 42 amino acids and derives from posttranslational processing of pre-pro-GIP, a protein consisting of 153 amino acids. It is structurally similar to members of the secretin/glucagon family that include secretin, glucagon, vasoactive intestinal peptide, and growth hormone-releasing factor(2). Growing evidence supports the physiological and pharmacological relevance of GIP in development of obesity and the pathogenesis of cardiovascular disease in addition to its involvement in type 2 diabetic pathophysiology(1,3). GIP acts in the entero-insular axis as an anabolic hormone that increases insulin levels, which in return increases the glycogen and fatty acid synthesis and inhibits the breakdown of fat. GIP also has extra pancreatic functions as well as roles in the stomach to reduce acid secretion by the parietal cells. On the bone, GIP has a dual effect as it causes proliferation of osteoblasts as well as inhibits osteoclastic bone resorption. The widespread expression of GIP-R in the brain suggests that GIP might play an essential function in neuro-signaling mechanisms(2).
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nReferences:
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n1. Fukuda M. The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity. Diabetes. 2021;70(9):1929-1937. doi:10.2337/dbi21-0001
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n2. Gupta K, Raja A. Physiology, Gastric Inhibitory Peptide. [Updated 2022 Sep 26]. StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK546653/
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n3. Heimbürger SM, Bergmann NC, Augustin R, Gasbjerg LS, Christensen MB, Knop FK. Glucose-dependent insulinotropic polypeptide (GIP) and cardiovascular disease. Peptides. 2020; 125:170174. doi: https://doi.org/10.1016/j.peptides.2019.170174

產(chǎn)品描述: The Intact GIP enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of GIP (1-42aa and 3-42aa) in human serum, plasma, and other biological fluids. The assay does not measure the truncated C-terminal fragment (1-30aa). This assay is intended for in vitro research use only.

產(chǎn)品特點

保存建議: Store at 2 to 8°C until expiration date.

其他: Ansh labs是開發(fā)和生產(chǎn)免疫檢測試劑盒和定制生物技術檢測產(chǎn)領創(chuàng)者，總部位于美國休斯敦，公司產(chǎn)品遍及全球80多個國家。公司于2011年成立，核心團隊來自于Diagnostic system laboratory，專注于女性健康和激素檢測領域近40年，擁有全球領先的核心技術，以及多年經(jīng)驗生物技術研發(fā)經(jīng)驗的科學家團隊，產(chǎn)品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個疾病領域，圍繞最新的免疫分析技術，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產(chǎn)品，也同時涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個物種的獨特的物種特異性的試劑。 Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產(chǎn)品研究和新型免疫檢測技術的先驅者。優(yōu)勢產(chǎn)品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。