Inhibin B is a dimeric hormone that is composed of alpha (α) and beta B (βB) subunits. The free alpha subunits usually do not have any physiological effect. Therefore, the bioactivity of the inhibins depends on the formation of a dimeric α-β structure, and only dimeric forms of inhibins are biologically active. Inhibins are protein hormones secreted by granulosa cells of the ovary in the female and sertoli cells of the testis in the male. They selectively suppress the secretion of pituitary follicle stimulating hormone (FSH) and also have local paracrine actions in the gonads. Inhibin B levels have been reported in sertoli cell function (potential marker for spermatogenesis and testicular function), ovarian reserve and granulosa cell tumors.
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nReferences:
n1. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n2. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available http:// www.cdc.gov/niosh.
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n4. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.
產(chǎn)品描述
The Inhibin B enzyme linked immunuosorbent assay (ELISA) kit provides materials for the quantitative measurement of Inhibin B in human serum and other biological fluids.