AMH，干血斑 ELISA （CE）-AMH, Dried Blood Spot ELISA (CE)代理/參數(shù)/廠家-ELISA試劑盒-艾美捷科技有限公司

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中文名稱: AMH，干血斑 ELISA （CE）

英文名字: AMH, Dried Blood Spot ELISA (CE)

供應(yīng)商: Ansh Labs

產(chǎn)品貨號: AL-129-i

產(chǎn)品報價: ￥詢價/96wellmicrotiter

產(chǎn)品說明書: 點擊查看

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產(chǎn)品新聞

背景資料: Anti-Müllerian hormone (AMH), a member of the TGF-β superfamily, is a homodimeric glycoprotein composed of two 55 kDa N-terminal and two 12.5 kDa C-terminal homodimers, non-covalently linked by disulfide bridges.1
n
nRecent studies have shown that the AMH C-terminal homodimer is much less active than the noncovalent complex, but almost all activity can be restored by associating with the N-terminal pro-region, which reforms a complex with the mature C-terminal homodimer. This finding raises the possibility that the AMH noncovalent complex is the active form of protein. It was reported that the cleaved AMH noncovalent complex binds to AMHRII and stimulates intracellular signaling, whereas full-length AMH shows only minimal activity.2
n
nAMH is secreted by the Sertoli cells in males. During embryonic development, AMH is responsible for Müllerian duct regression. AMH continues to be produced by the testes until puberty and then decreases slowly to residual post-puberty values. In females, AMH is produced by the granulosa cells of small growing follicles from the 36th week of gestation onwards until menopause when levels become undetectable. Potential clinical applications of low end anti-müllerian hormone (AMH) have been published in premature ovarian insufficiency, ovarian tumors, menopause and many more.
n
nReferences:
n1. Pepinski, R.B., et al. (1988) J. Biol. Chem., 263, 18961-18964.
n2. di Clemente et al. Mol Endocrinol, November 2010, 24 (11): 2193-2206.
n3. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n4. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available http:// www.cdc.gov/niosh.
n5. Approved Guideline – Procedures for the Handling and Processing of Blood Specimens, H18-A3. 2004. Clinical and Laboratory Standards Institute.
n6. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.

產(chǎn)品描述: Dried blood spot specimens stability makes it a practical alternative?to venous blood. It opens new possibilities in AMH testing, such?as comparison of historical to current patient results; simplified?blood sampling for patients in remote locations or for those who are?homebound. Instead of traveling to a clinic to get blood drawn, a blood?spot sample can be taken at a convenient site and mailed to a laboratory.?This technology will be especially useful for monitoring ovarian function?of physically challenged cancer patients undergoing chemotherapy.

產(chǎn)品特點

保存建議: Store at 2 to 8°C until expiration date.

其他: Ansh labs是開發(fā)和生產(chǎn)免疫檢測試劑盒和定制生物技術(shù)檢測產(chǎn)領(lǐng)創(chuàng)者，總部位于美國休斯敦，公司產(chǎn)品遍及全球80多個國家。公司于2011年成立，核心團隊來自于Diagnostic system laboratory，專注于女性健康和激素檢測領(lǐng)域近40年，擁有全球領(lǐng)先的核心技術(shù)，以及多年經(jīng)驗生物技術(shù)研發(fā)經(jīng)驗的科學家團隊，產(chǎn)品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個疾病領(lǐng)域，圍繞最新的免疫分析技術(shù)，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產(chǎn)品，也同時涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個物種的獨特的物種特異性的試劑。 Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產(chǎn)品研究和新型免疫檢測技術(shù)的先驅(qū)者。優(yōu)勢產(chǎn)品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。