PAPP-A（小鼠）ELISA-PAPP-A (Mouse) ELISA代理/參數(shù)/廠家-ELISA試劑盒-艾美捷科技有限公司

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中文名稱: PAPP-A（小鼠）ELISA

英文名字: PAPP-A (Mouse) ELISA

供應(yīng)商: Ansh Labs

產(chǎn)品貨號(hào): AL-158

產(chǎn)品報(bào)價(jià): ￥詢價(jià)/96wellmicrotiter

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產(chǎn)品新聞

背景資料: Pregnancy-associated plasma protein-A (PAPP-A) is a novel zinc metalloproteinase that functions in many systems outside of pregnancy. PAPP-A expression has been reported in various tissues, including endometrium, testis, kidney, bone, colon, and other adult and fetal tissues.1-12 Abundant PAPP-A mRNA expression levels were found in visceral fat and these were 10-fold higher than in subcutaneous fat.10 PAPP-A expression significantly increases with age in kidney, brain and gonads10 and significantly deceases with age in bone and skeletal muscle.10 In the thymus, PAPP-A mRNA showed a biphasic response with age.10 Data in both humans and mice suggest a role for PAPP-A in aging and age-related diseases.10 Expression of IGFBP-5 mRNA, a marker of insulin-like growth factor-I (IGF-I) bioactivity known to be regulated by PAPP-A, paralleled the changes in PAPP-A expression with age in kidney, bone, skeletal muscle and thymus. PAPP-A is potentially proatherosclerotic and has been proposed as a new marker of inflammation, as high serum PAPP-A levels are observed in patients with renal impairment, asthma, lung cancer, etc.1-12 Stimulation of PAPP-A expression by intermittent PTH treatment contributes to PTH bone anabolism in mice.9 Effect of PAPP-A on tendon structure and mechanical properties have been studied8, However, quantitative determination of PAPP-A in mouse tissues with age are limited due to unavailability of the mouse PAPP-A ELISA.
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nReferences:
n1. Bulut I, Coskun A, Ciftci A et al. Relationship between Pregnancy associated plasma protein A and lung cancer. The American Journal of the Medical sciences. April 2009; 337 (4): 241-244
n2. Schindler AM, Bischof B. Histochemical localization of pregnancy associated plasma protein-A in fetal, infant, and adult organs and camparison between antisera. Gynecol Obstet Invest. 1984; 18: 88-94.
n3. Overgaard MT, Oxvig C, Christiansen M , et al. Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the preform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissue. Biol Reprod 1999; 61:1083-1089.
n4. Fialova L, Kalousova M, Soukupova J, et al. Relationship of pregnancy associated plasma protein A to renal function and dialysis modalities. Kidney Blood Press Res. 2004; 27: 88-95.
n5. Coskun A, Balbay O, Duran S et al. Pregnancy-associated plasma protein A and asthama. Adv Ther. 2007; 24: 362-367.
n6. Coskun A, Duran S, Apaydin S, et al. Pregnancy-associated plasma protein A: evaluation of a new biomarker in renal transplanted patients. Transplant Proc. 2007; 39:3072-3076.
n7. Bayes-Genis A, Conover CA, Overgaard MT, et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med. 2001; 345: 1022-1029.
n8. Yang TH, et al. PAPP-A affects tendon structure and mechanical properties. J Struct Biol. Oct 2015; 192(1):59-66.
n9. Clifton KB, et al. Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone. Bone. Dec 2015; 81:413-6.
n10. Harstad SL, et al. Tissue-specific changes in pregnancy associated plasma protein-A expression with age in mice. Endocrinology. Sep 2014; 57:13-7.
n11. Bale LK, et al. Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice. Endocrinology, Apr 2014; 155(4):1184-7.
n12. Conover CA, et al. Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet. Am J Physiol Endocrinol Metab. Nov 2013; 305(9):E1145-53.
n13. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n14. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available http:// www.cdc.gov/niosh.
n15. Approved Guideline – Procedures for the Handling and Processing of Blood Specimens, H18-A3. 2004. Clinical and Laboratory Standards Institute.
n16. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.

產(chǎn)品描述: The Mouse PAPP-A enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of PAPP-A in mouse serum, cell supernatant, and other biological fluids.

產(chǎn)品特點(diǎn)

保存建議: Store at 2 to 8°C until expiration date.

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