- 中文名稱
PAPP-A / Stanniocalcin 2 復(fù)合物 ELISA
- 英文名字
- PAPP-A / Stanniocalcin 2 Complex ELISA
- 供應(yīng)商
- Ansh Labs
- 產(chǎn)品貨號
- AL-166
- 產(chǎn)品報(bào)價(jià)
- ￥詢價(jià)/96wellmicrotiter
- 產(chǎn)品說明書
- 點(diǎn)擊查看
- 購買方式
- 90%產(chǎn)品中國有現(xiàn)貨庫存。銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868
- 產(chǎn)品新聞
- 背景資料
- Mammalian stanniocalcin-2 (STC2) is a secreted polypeptide widely expressed in developing and adult tissues. However, although transgenic expression in mice is known to cause severe dwarfism, and targeted deletion of STC2 causes increased postnatal growth, its precise biological role has remained unknown. STC2 potently inhibits the proteolytic activity of the growth promoting metalloproteinase, pregnancy associated plasma protein-A (PAPP-A). Proteolytic inhibition requires covalent binding of STC2 to PAPPA, and is mediated by a disulfide bond, which involves Cys120 of STC2. Binding of STC2 prevents PAPP-A cleavage of insulin-like growth factor binding protein (IGFBP)-4 and hence release within tissues of bioactive IGF, required for normal growth. Concordantly, STC2 efficiently inhibits PAPP-Amediated IGF receptor signaling in vitro, and that transgenic mice expressing a mutated variant of STC2, STC2(C120A), which is unable to inhibit PAPPA, grow like wild-type mice. STC2 is a novel proteinase inhibitor and a previously unrecognized extracellular component of the IGF system.1
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nREFERENCES
n1. Malene R. Jepsen, S?ren Kl?verpris , Jakob H. Mikkelsen , Josefine H. Pedersen, Ernst-Martin Füchtbauer, Lisbeth S. Laursen, and Claus Oxvig JBC Papers in Press. Published on December 22, 2014 as Manuscript M114.611665.
- 產(chǎn)品描述
- The PAPP-A Stanniocalcin-2 Complex enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of PAPP-A Stanniocalcin-2 Complex in human serum and other biological fluids.
- 產(chǎn)品特點(diǎn)
- 保存建議
- Store at 2 to 8°C until expiration date.
- 其他
- Ansh labs是開發(fā)和生產(chǎn)免疫檢測試劑盒和定制生物技術(shù)檢測產(chǎn)領(lǐng)創(chuàng)者，總部位于美國休斯敦，公司產(chǎn)品遍及全球80多個(gè)國家。公司于2011年成立，核心團(tuán)隊(duì)來自于Diagnostic system laboratory，專注于女性健康和激素檢測領(lǐng)域近40年，擁有全球領(lǐng)先的核心技術(shù)， 以及多年經(jīng)驗(yàn)生物技術(shù)研發(fā)經(jīng)驗(yàn)的科學(xué)家團(tuán)隊(duì)，產(chǎn)品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個(gè)疾病領(lǐng)域，圍繞最新的免疫分析技術(shù)，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產(chǎn)品，也同時(shí)涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個(gè)物種的獨(dú)特的物種特異性的試劑。
Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測公司，也是最早專注激素類產(chǎn)品研究和新型免疫檢測技術(shù)的先驅(qū)者。優(yōu)勢產(chǎn)品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。
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- 注意
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